Salvia Leads Chemists on a Psychedelic Existential Journey

On August 2, synthetic organic chemist Ryan Shenvi stood before 300 people at the Natural Products and Bioactive Compounds conference and told them something he knew was sacrilegious: He’d synthesized salvinorin A, the active ingredient in the wildly intense hallucinogen salvia, and he hadn’t just copied a molecule, as synthetic organic chemists are wont to …